| Pos. | Team | GP | W | D | L | GF | GA | +/- | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Columbus Crew | 27 | 16 | 5 | 6 | 46 | 31 | 15 | 53 |
| 2 | New England Revolution | 27 | 12 | 7 | 8 | 38 | 37 | 1 | 43 |
| 3 | Chicago Fire | 27 | 12 | 6 | 9 | 35 | 26 | 9 | 42 |
| 4 | New York Red Bulls | 27 | 9 | 8 | 10 | 36 | 41 | -5 | 35 |
| 5 | Kansas City Wizards | 27 | 8 | 9 | 10 | 30 | 36 | -6 | 33 |
| 6 | D.C. United | 27 | 10 | 3 | 14 | 41 | 49 | -8 | 33 |
| 7 | Toronto FC | 27 | 8 | 7 | 12 | 29 | 37 | -8 | 31 |
| Pos. | Team | GP | W | D | L | GF | GA | +/- | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Houston Dynamo | 26 | 11 | 10 | 5 | 39 | 30 | 9 | 43 |
| 2 | Chivas USA | 27 | 11 | 6 | 10 | 37 | 38 | -1 | 39 |
| 3 | Real Salt Lake | 27 | 9 | 8 | 10 | 35 | 36 | -1 | 35 |
| 4 | FC Dallas | 27 | 8 | 10 | 9 | 40 | 34 | 6 | 34 |
| 5 | Colorado Rapids | 27 | 10 | 4 | 13 | 39 | 40 | -1 | 34 |
| 6 | San Jose Earthquakes | 26 | 7 | 9 | 10 | 27 | 32 | -5 | 30 |
| 7 | Los Angeles Galaxy | 27 | 7 | 8 | 12 | 50 | 55 | -5 | 29 |
| 09/10/08 | Real Salt Lake | vs. | New York |
| 11/10/08 | Kansas City | vs. | New England |
| 11/10/08 | San Jose | vs. | CD Chivas USA |
| 11/10/08 | FC Dallas | vs. | Toronto FC |
| 12/10/08 | Chicago | vs. | Columbus |
| 12/10/08 | Los Angeles | vs. | Colorado |
| 12/10/08 | Houston | vs. | D.C. United |
| Player | Team | Goals |
|---|---|---|
| Landon Donovan | Los Angeles Galaxy | 19 |
| Kenny Cooper | FC Dallas | 16 |
| Edson Buddle | Los Angeles Galaxy | 13 |
| Brian Ching | Houston Dynamo | 12 |
| Juan Pablo Angel | New York Red Bulls | 11 |
| Luciano Emilio | D.C. United | 11 |
| Jaime Moreno | D.C. United | 10 |
| Chad Barrett | Toronto FC | 9 |
| Conor Casey | Colorado Rapids | 9 |
| Alejandro Moreno | Columbus Crew | 9 |
| Jeff Cunningham | FC Dallas | 8 |
| Steve Ralston | New England Revolution | 8 |
| Taylor Twellman | New England Revolution | 7 |
| Arturo Alvarez | San Jose Earthquakes | 6 |
| Guillermo Barros Schelotto | Columbus Crew | 6 |
