| 04/09/08 | FC Dallas | 0 : 1 | Colorado |
| 06/09/08 | Toronto FC | 1 : 3 | CD Chivas USA |
| 06/09/08 | San Jose | 2 : 1 | D.C. United |
| 06/09/08 | Chicago | 1 : 0 | New York |
| 06/09/08 | Columbus | 4 : 0 | New England |
| 06/09/08 | Los Angeles | 2 : 2 | Real Salt Lake |
| 07/09/08 | Houston | 3 : 1 | Kansas City |
| 11/09/08 | New England | 4 : 0 | CD Chivas USA |
| 13/09/08 | San Jose | 1 : 1 | Houston |
| 13/09/08 | Toronto FC | 1 : 1 | Columbus |
| 13/09/08 | Kansas City | 2 : 0 | Los Angeles |
| 13/09/08 | D.C. United | 2 : 2 | FC Dallas |
| 13/09/08 | New York | 2 : 1 | Real Salt Lake |
| 14/09/08 | Colorado | 2 : 0 | Chicago |
| 18/09/08 | Columbus | 3 : 1 | New York |
| 20/09/08 | Colorado | 1 : 1 | New England |
| 20/09/08 | Kansas City | 2 : 0 | Toronto FC |
| 20/09/08 | Real Salt Lake | 0 : 1 | CD Chivas USA |
| 20/09/08 | Los Angeles | 5 : 2 | D.C. United |
| 21/09/08 | Chicago | 1 : 4 | FC Dallas |
| 25/09/08 | Chicago | 3 : 1 | Los Angeles |
| 27/09/08 | Toronto FC | 1 : 1 | Houston |
| 27/09/08 | San Jose | 2 : 3 | Real Salt Lake |
| 27/09/08 | New England | 0 : 1 | Columbus |
| 27/09/08 | New York | 4 : 5 | Colorado |
| 27/09/08 | CD Chivas USA | 2 : 1 | Kansas City |
| 28/09/08 | FC Dallas | vs. | D.C. United |
