| 02/10/08 | FC Dallas | 1 : 1 | San Jose |
| 04/10/08 | Colorado | 1 : 3 | Houston |
| 04/10/08 | Columbus | 1 : 0 | Los Angeles |
| 04/10/08 | D.C. United | 0 : 3 | CD Chivas USA |
| 04/10/08 | New England | 2 : 2 | Real Salt Lake |
| 04/10/08 | New York | 1 : 3 | Toronto FC |
| 05/10/08 | Kansas City | 1 : 1 | Chicago |
| 09/10/08 | Real Salt Lake | 1 : 1 | New York |
| 11/10/08 | Kansas City | 1 : 0 | New England |
| 11/10/08 | San Jose | 2 : 2 | CD Chivas USA |
| 11/10/08 | FC Dallas | 2 : 2 | Toronto FC |
| 12/10/08 | Chicago | 2 : 2 | Columbus |
| 12/10/08 | Los Angeles | 3 : 2 | Colorado |
| 12/10/08 | Houston | 0 : 0 | D.C. United |
| 16/10/08 | D.C. United | 2 : 1 | New England |
| 18/10/08 | Toronto FC | 3 : 2 | Chicago |
| 18/10/08 | Kansas City | 3 : 2 | San Jose |
| 18/10/08 | Real Salt Lake | 3 : 1 | FC Dallas |
| 18/10/08 | New York | 3 : 2 | Columbus |
| 18/10/08 | Houston | 3 : 0 | Los Angeles |
| 19/10/08 | CD Chivas USA | 1 : 2 | Colorado |
| 23/10/08 | Chicago | 5 : 2 | New York |
| 25/10/08 | San Jose | 2 : 0 | Toronto FC |
| 25/10/08 | Colorado | 1 : 1 | Real Salt Lake |
| 25/10/08 | New England | 1 : 3 | Kansas City |
| 25/10/08 | CD Chivas USA | 1 : 1 | Houston |
| 26/10/08 | Los Angeles | 2 : 2 | FC Dallas |
| 26/10/08 | Columbus | 1 : 0 | D.C. United |
