| 01/05/08 | Toronto FC | 1 : 1 | New York |
| 03/05/08 | San Jose | 0 : 0 | FC Dallas |
| 03/05/08 | Real Salt Lake | 2 : 2 | Los Angeles |
| 03/05/08 | Columbus | 2 : 1 | Kansas City |
| 03/05/08 | New England | 0 : 3 | Chicago |
| 03/05/08 | Houston | 0 : 0 | CD Chivas USA |
| 04/05/08 | Colorado | 2 : 0 | D.C. United |
| 08/05/08 | D.C. United | 0 : 2 | Chicago |
| 10/05/08 | San Jose | 2 : 3 | Columbus |
| 10/05/08 | Real Salt Lake | 2 : 1 | FC Dallas |
| 10/05/08 | Los Angeles | 1 : 2 | New York |
| 10/05/08 | Houston | 2 : 1 | Colorado |
| 11/05/08 | CD Chivas USA | 1 : 2 | New England |
| 15/05/08 | Colorado | 2 : 0 | Real Salt Lake |
| 17/05/08 | Toronto FC | 0 : 0 | Columbus |
| 17/05/08 | Chicago | 1 : 2 | Houston |
| 17/05/08 | New England | 2 : 0 | San Jose |
| 17/05/08 | New York | 1 : 1 | Kansas City |
| 17/05/08 | CD Chivas USA | 3 : 1 | D.C. United |
| 18/05/08 | FC Dallas | 1 : 5 | Los Angeles |
| 21/05/08 | Toronto FC | 1 : 0 | D.C. United |
| 22/05/08 | San Jose | 2 : 1 | Houston |
| 24/05/08 | Colorado | 1 : 2 | CD Chivas USA |
| 24/05/08 | Columbus | 0 : 1 | New England |
| 24/05/08 | FC Dallas | 2 : 1 | Real Salt Lake |
| 24/05/08 | D.C. United | 3 : 2 | Toronto FC |
| 24/05/08 | Los Angeles | 3 : 1 | Kansas City |
| 25/05/08 | New York | 1 : 5 | Chicago |
| 28/05/08 | FC Dallas | 2 : 2 | Houston |
| 29/05/08 | New England | 2 : 2 | D.C. United |
| 31/05/08 | Toronto FC | 2 : 0 | Los Angeles |
| 31/05/08 | Real Salt Lake | 3 : 1 | San Jose |
| 31/05/08 | CD Chivas USA | 2 : 0 | Columbus |
| 31/05/08 | Houston | 1 : 0 | New York |
