| 02/08/08 | Chicago | 1 : 0 | CD Chivas USA |
| 02/08/08 | D.C. United | 2 : 0 | Kansas City |
| 02/08/08 | Houston | 2 : 0 | Columbus |
| 03/08/08 | San Jose | 3 : 2 | Los Angeles |
| 03/08/08 | Toronto FC | 0 : 2 | FC Dallas |
| 09/08/08 | Colorado | 0 : 1 | Toronto FC |
| 09/08/08 | Kansas City | 3 : 2 | CD Chivas USA |
| 09/08/08 | New England | 1 : 2 | Chicago |
| 10/08/08 | New York | 4 : 1 | D.C. United |
| 14/08/08 | CD Chivas USA | 2 : 2 | Los Angeles |
| 16/08/08 | San Jose | 4 : 0 | New England |
| 16/08/08 | Chicago | 0 : 1 | D.C. United |
| 16/08/08 | Colorado | 2 : 1 | Kansas City |
| 16/08/08 | Columbus | 2 : 1 | FC Dallas |
| 16/08/08 | Houston | 4 : 3 | Real Salt Lake |
| 17/08/08 | New York | 2 : 0 | Toronto FC |
| 20/08/08 | New England | 2 : 1 | D.C. United |
| 20/08/08 | Houston | 4 : 0 | CD Chivas USA |
| 21/08/08 | Los Angeles | 0 : 1 | Chicago |
| 23/08/08 | Kansas City | 1 : 1 | FC Dallas |
| 23/08/08 | Columbus | 3 : 0 | Real Salt Lake |
| 23/08/08 | D.C. United | 3 : 0 | Colorado |
| 23/08/08 | CD Chivas USA | 0 : 0 | San Jose |
| 23/08/08 | Toronto FC | 1 : 1 | New England |
| 24/08/08 | New York | 3 : 0 | Houston |
| 29/08/08 | Real Salt Lake | 2 : 0 | Colorado |
| 30/08/08 | San Jose | 2 : 1 | Kansas City |
| 30/08/08 | D.C. United | 0 : 0 | New York |
| 30/08/08 | New England | 2 : 2 | Los Angeles |
| 30/08/08 | CD Chivas USA | 2 : 1 | Toronto FC |
| 30/08/08 | FC Dallas | 1 : 2 | Columbus |
| 31/08/08 | Houston | 2 : 1 | Chicago |
