| 03/04/08 | Chicago | 4 : 0 | New England |
| 03/04/08 | Los Angeles | 2 : 0 | San Jose |
| 05/04/08 | Kansas City | 3 : 2 | Colorado |
| 05/04/08 | D.C. United | 4 : 1 | Toronto FC |
| 05/04/08 | New York | 2 : 0 | Columbus |
| 05/04/08 | CD Chivas USA | 3 : 1 | Real Salt Lake |
| 06/04/08 | Houston | 3 : 3 | FC Dallas |
| 09/04/08 | Kansas City | 1 : 3 | New England |
| 12/04/08 | San Jose | 0 : 1 | Chicago |
| 12/04/08 | Kansas City | 0 : 0 | Houston |
| 12/04/08 | Real Salt Lake | 4 : 0 | D.C. United |
| 12/04/08 | Columbus | 4 : 3 | CD Chivas USA |
| 12/04/08 | FC Dallas | 2 : 0 | New York |
| 12/04/08 | New England | 0 : 1 | Colorado |
| 13/04/08 | Los Angeles | 2 : 3 | Toronto FC |
| 17/04/08 | D.C. United | 1 : 2 | Columbus |
| 19/04/08 | Toronto FC | 1 : 0 | Real Salt Lake |
| 19/04/08 | Colorado | 0 : 2 | San Jose |
| 19/04/08 | Los Angeles | 2 : 2 | Houston |
| 19/04/08 | New York | 1 : 1 | New England |
| 20/04/08 | Chicago | 0 : 1 | Kansas City |
| 20/04/08 | CD Chivas USA | 0 : 2 | FC Dallas |
| 24/04/08 | FC Dallas | 0 : 1 | New England |
| 26/04/08 | Toronto FC | 2 : 0 | Kansas City |
| 26/04/08 | Chicago | 2 : 1 | Colorado |
| 26/04/08 | Columbus | 1 : 0 | Houston |
| 26/04/08 | D.C. United | 4 : 1 | Real Salt Lake |
| 26/04/08 | Los Angeles | 5 : 2 | CD Chivas USA |
| 27/04/08 | New York | 2 : 0 | San Jose |
