| 01/09/07 | Levante | 0-0 | Murcia |
| 01/09/07 | Zaragoza Oliveira 74 | 1-1 | Racing Oscar Serrano 54 |
| 02/09/07 | UD Almeria Negredo 64 | 1-2 | Valencia Morientes 46, Moretti 80 |
| 02/09/07 | Valladolid Garcia Calvo 45, Sisi 70 | 2-2 | Deportivo Taborda 51, Riki 75 |
| 02/09/07 | Betis Fernando 82, Rafael Sobis 84 | 2-2 | Espanyol Luis Garcia 32, 41 |
| 02/09/07 | Getafe Manu 90 | 1-1 | Recreativo Sinama Pongolle 84 |
| 02/09/07 | Barcelona Ronaldinho 7, 34(p), Toure Yaya 72 | 3-1 | Athletic Susaeta 71 |
| 02/09/07 | Atlético Pernia 76 | 1-1 | Mallorca Guiza 19 |
| 02/09/07 | Villarreal | 0-5 | Real Madrid Raul 39, Sneijder 47, 71, van Nistelrooy 49, Guti 78 |
| 15/09/07 | Real Madrid Saviola 36, Sneijder 69, Higuain 87 | 3-1 | UD Almeria Uche 72 |
| 15/09/07 | Valencia Morientes 24, Silva 90 | 2-1 | Valladolid Kome 9 |
| 15/09/07 | Athletic Susaeta 8 | 1-1 | Zaragoza Diego Milito 15 |
| 16/09/07 | Racing Munitis 27 | 1-0 | Levante |
| 16/09/07 | Murcia Gallardo 79 | 1-1 | Atlético Aguero 13 |
| 16/09/07 | Mallorca | 0-1 | Villarreal Nihat 81 |
| 16/09/07 | Deportivo Lafita 8 | 1-0 | Betis |
| 16/09/07 | Espanyol Jonathan 87 | 1-0 | Getafe |
| 16/09/07 | Sevilla Kerzhakov 12, 73, Kanoute 35, 53 | 4-1 | Recreativo Aitor 57 |
| 16/09/07 | Osasuna | 0-0 | Barcelona |
| 22/09/07 | Recreativo Javi Guerrero 53, 59 | 2-1 | Espanyol Riera 5 |
| 22/09/07 | Barcelona Messi 73, 79(p) | 2-1 | Sevilla Kanoute 90 |
| 23/09/07 | Villarreal Rossi 84, 88 | 2-0 | Murcia |
| 23/09/07 | UD Almeria Mane 33 | 1-1 | Mallorca Guiza 77 |
| 23/09/07 | Getafe | 0-0 | Deportivo |
| 23/09/07 | Zaragoza Matuzalem 16, Diego Milito 70(p) | 2-1 | Osasuna Juanfran 24 |
| 23/09/07 | Levante Rigano 76 | 1-2 | Athletic Aduriz 7, 72 |
| 23/09/07 | Betis Rafael Sobis 86 | 1-2 | Valencia Miguel 68, Joaquin 82 |
| 23/09/07 | Atlético Raul Garcia 11, Aguero 69, Forlan 76, Simao 85 | 4-0 | Racing |
| 23/09/07 | Valladolid Pedro Lopez 70 | 1-1 | Real Madrid Saviola 86 |
| 25/09/07 | Sevilla Torrejon 60(o), Kone 68 | 2-3 | Espanyol Angel 28, Luis Garcia 53, Tamudo 87 |
| 26/09/07 | Racing | 0-2 | Villarreal Nihat 39, Rossi 78 |
| 26/09/07 | Murcia | 0-1 | UD Almeria Felipe Melo 42 |
| 26/09/07 | Mallorca Nunes 47, Arango 49, 85, Victor 81 | 4-2 | Valladolid Ogbeche 5, Victor 25 |
| 26/09/07 | Valencia Silva 15, Villa 31 | 2-1 | Getafe Braulio 75 |
| 26/09/07 | Deportivo | 0-2 | Recreativo Carlos Martins 11, Javi Guerrero 46 |
| 26/09/07 | Osasuna Pandiani 31, 51, Juanfran 56, Javi Garcia 76 | 4-1 | Levante Ettien 33 |
| 26/09/07 | Athletic | 0-2 | Atlético Aguero 12, Forlan 77 |
| 26/09/07 | Barcelona Messi 4, 10, Iniesta 21, Marquez 45 | 4-1 | Zaragoza Zapater 9 |
| 27/09/07 | Real Madrid Raul 66(p), Julio Baptista 84 | 2-0 | Betis |
| 29/09/07 | Zaragoza D'Alessandro 52, Sergio Garcia 86 | 2-0 | Sevilla |
| 29/09/07 | Levante Viqueira 71(p) | 1-4 | Barcelona Henry 16, 23, 48, Messi 50 |
| 30/09/07 | Atlético Raul Garcia 37, Aguero 81 | 2-0 | Osasuna |
| 30/09/07 | Villarreal Fuentes 62 | 1-0 | Athletic |
| 30/09/07 | UD Almeria | 0-1 | Racing Garay 9 |
| 30/09/07 | Valladolid Llorente 47 | 1-4 | Murcia De Lucas 28, Baiano 74, Ivan Alonso 79, Abel 86 |
| 30/09/07 | Betis Xisco 58, Rafael Sobis 77, Edu 90 | 3-0 | Mallorca |
| 30/09/07 | Espanyol Tamudo 45 | 1-0 | Deportivo |
| 30/09/07 | Getafe | 0-1 | Real Madrid Sergio Ramos 64 |
| 30/09/07 | Recreativo | 0-1 | Valencia Villa 4 |
