| 06/10/07 | Valencia Baraja 4 | 1-2 | Espanyol Riera 20, Luis Garcia 79 |
| 07/10/07 | Zaragoza Sergio Garcia 63, Oliveira 69, 81 | 3-0 | Levante |
| 07/10/07 | Barcelona Deco 16, Messi 19, Xavi 89 | 3-0 | Atlético |
| 07/10/07 | Osasuna Juanfran 20, Dady 33, Javi Garcia 78 | 3-2 | Villarreal Rossi 19, Godin 35 |
| 07/10/07 | Athletic Etxeberria 31 | 1-1 | UD Almería Felipe Melo 61 |
| 07/10/07 | Murcia | 0-0 | Betis |
| 07/10/07 | Mallorca Ibagaza 54(p), Arango 71, 78, Ramis 90 | 4-2 | Getafe Sousa 2, 47 |
| 07/10/07 | Real Madrid van Nistelrooy 72, Higuain 90 | 2-0 | Recreativo |
| 07/10/07 | Sevilla | 0-1 | Deportivo Riki 72 |
| 07/10/07 | Racing Smolarek 52, Tchite 88 | 2-0 | Valladolid |
| 20/10/07 | Levante | 0-2 | Sevilla Luis Fabiano 6, 13(p) |
| 20/10/07 | Villarreal Santi Cazorla 2, Senna 13(p), 34(p) | 3-1 | Barcelona Bojan 24 |
| 20/10/07 | Deportivo Xisco 28, Bodipo 87 | 2-4 | Valencia Joaquin 9(p), Baraja 15, Morientes 37, 73 |
| 20/10/07 | Espanyol Riera 1, Tamudo 52 | 2-1 | Real Madrid Sergio Ramos 89 |
| 21/10/07 | UD Almería Felipe Melo 53(p), Negredo 70 | 2-0 | Osasuna |
| 21/10/07 | Valladolid Victor 70(p) | 1-2 | Athletic Aduriz 8, 31 |
| 21/10/07 | Betis Xisco 62 | 1-1 | Racing Jorge Lopez 87 |
| 21/10/07 | Getafe Kepa 55, Casquero 59 | 2-0 | Murcia |
| 21/10/07 | Recreativo | 0-2 | Mallorca Guiza 2, Tuni 78 |
| 21/10/07 | Atlético Luis Garcia 9, Forlan 34, Maxi 63(p), 90 | 4-0 | Zaragoza |
| 27/10/07 | Mallorca Arango 2, Guiza 68 | 2-2 | Espanyol Arango 20(o), Tamudo 26(p) |
| 27/10/07 | Athletic | 0-0 | Betis |
| 28/10/07 | Real Madrid van Nistelrooy 7(p), Raul 77, Robinho 88 | 3-1 | Deportivo Xisco 1 |
| 28/10/07 | Osasuna Dady 73, 78 | 2-2 | Valladolid Alvaro Rubio 35, Sesma 51 |
| 28/10/07 | Racing Oscar Serrano 39, Jorge Lopez 74 | 2-0 | Getafe |
| 28/10/07 | Murcia Regueiro 46 | 1-0 | Recreativo |
| 28/10/07 | Levante | 0-1 | Atlético Forlan 26 |
| 28/10/07 | Zaragoza Oliveira 36, Oscar 49, Diego Milito 66(p), Sergio Garcia 78 | 4-1 | Villarreal Pires 81 |
| 28/10/07 | Barcelona Henry 36, Messi 80(p) | 2-0 | UD Almería |
| 28/10/07 | Sevilla Kanoute 9, Poulsen 72, Luis Fabiano 85 | 3-0 | Valencia |
| 31/10/07 | Villarreal Franco 2, Rossi 14(p), Cygan 37 | 3-0 | Levante |
| 31/10/07 | UD Almería | 0-1 | Zaragoza Diego Milito 77(p) |
| 31/10/07 | Betis | 0-3 | Osasuna Cruchaga 42, Dady 53, Vela 56 |
| 31/10/07 | Getafe Casquero 9, Uche 29 | 2-0 | Athletic |
| 31/10/07 | Recreativo | 0-0 | Racing |
| 31/10/07 | Deportivo Guardado 41(p) | 1-1 | Mallorca Guiza 11 |
| 31/10/07 | Valencia Angulo 58 | 1-5 | Real Madrid Raul 2, van Nistelrooy 25, 36, Sergio Ramos 30, Robinho 64 |
| 31/10/07 | Atlético Maniche 1, Aguero 16, Maxi 69, Jurado 90 | 4-3 | Sevilla Luis Fabiano 13, 90, Ze Castro 44(o) |
