| 03/05/08 | Atlético Camacho 24, 75, Aguero 55 | 3-0 | Recreativo |
| 03/05/08 | Zaragoza Ayala 90 | 1-0 | Deportivo |
| 04/05/08 | Athletic Llorente 8 | 1-2 | Mallorca Guiza 3, 71 |
| 04/05/08 | Racing Munitis 36, 58, Jorge Lopez 47 | 3-2 | Murcia Aquino 13, Ivan Alonso 28 |
| 04/05/08 | Sevilla Renato 10, 40 | 2-0 | Valladolid |
| 04/05/08 | Almería Pulido 47 | 1-1 | Betis Odonkor 44 |
| 04/05/08 | Villarreal Nihat 37, 44 | 2-0 | Getafe |
| 04/05/08 | Levante Juanma 77 | 1-1 | Espanyol Luis Garcia 90(p) |
| 04/05/08 | Barcelona Messi 6(p), Xavi 8, Henry 14, 58, Bojan 72, 79 | 6-0 | Valencia |
| 04/05/08 | Osasuna Punal 83(p) | 1-2 | Real Madrid Robben 88, Higuain 89 |
| 07/05/08 | Betis Gonzalez 51(p) | 1-1 | Valladolid Victor 63 |
| 07/05/08 | Getafe Albin 33, Manu 62, 67, Granero 74(p) | 4-2 | Almería Crusat 5, Paunovic 11 |
| 07/05/08 | Recreativo | 0-2 | Villarreal Nihat 53, Franco 82 |
| 07/05/08 | Deportivo Riki 87 | 1-0 | Levante |
| 07/05/08 | Valencia Silva 19 | 1-0 | Zaragoza |
| 07/05/08 | Mallorca Guiza 32, Trejo 90 | 2-1 | Osasuna Portillo 73 |
| 07/05/08 | Murcia Ivan Alonso 22 | 1-2 | Athletic Llorente 34, Gabilondo 82 |
| 07/05/08 | Racing | 0-3 | Sevilla Fazio 30, 65, Renato 90 |
| 07/05/08 | Real Madrid Raul 13, Robben 21, Higuain 63, van Nistelrooy 78(p) | 4-1 | Barcelona Henry 87 |
| 08/05/08 | Espanyol | 0-2 | Atlético Aguero 27, Forlan 30 |
| 11/05/08 | Betis | 0-2 | Sevilla Luis Fabiano 33, Fazio 51 |
| 11/05/08 | Valladolid | 0-0 | Getafe |
| 11/05/08 | Almería | 0-2 | Recreativo Jesus Vazquez 25, Sinama Pongolle 42 |
| 11/05/08 | Villarreal Javi Venta 31, Pires 43 | 2-0 | Espanyol |
| 11/05/08 | Atlético Forlan 45 | 1-0 | Deportivo |
| 11/05/08 | Levante Serrano 32 | 1-5 | Valencia Villa 14, 30, 65, Mata 35, Angulo 64 |
| 11/05/08 | Zaragoza Oliveira 19, Sergio 86 | 2-2 | Real Madrid van Nistelrooy 27, Robinho 77 |
| 11/05/08 | Barcelona Henry 16, Eto'o 56 | 2-3 | Mallorca Borja Valero 67, Webo 70, Guiza 90 |
| 11/05/08 | Osasuna Dady 1, Juanfran 53 | 2-1 | Murcia Abel 90 |
| 11/05/08 | Athletic | 0-0 | Racing |
| 17/05/08 | Murcia Ochoa 17, Ivan Alonso 82(p), Abel 85 | 3-5 | Barcelona Eto'o 24, Henry 26, Giovanni 33, 52, 66 |
| 18/05/08 | Getafe Manu 4 | 1-1 | Betis Nano 69 |
| 18/05/08 | Recreativo Javi Guerrero 90 | 1-1 | Valladolid Llorente 40 |
| 18/05/08 | Valencia Seitaridis 11(o), Villa 40, 55 | 3-1 | Atlético Aguero 75 |
| 18/05/08 | Mallorca Guiza 15, Webo 65, Castro 90 | 3-2 | Zaragoza Oliveira 55, 90 |
| 18/05/08 | Racing Bolado 85 | 1-0 | Osasuna |
| 18/05/08 | Sevilla Kanoute 38, 81, Keita 78, Jesus Navas 88 | 4-1 | Athletic Aduriz 3(p) |
| 18/05/08 | Real Madrid van Nistelrooy 23, 41, Sergio Ramos 28, 78, Sneijder 55 | 5-2 | Levante Geijo 53, 64 |
| 18/05/08 | Deportivo | 0-2 | Villarreal Fernandez 35, Franco 90 |
| 18/05/08 | Espanyol Luis Garcia 59(p) | 1-3 | Almería Felipe Melo 44, Crusat 54, Paunovic 90 |
