| 05/01/08 | Mallorca | 0-2 | Barcelona Marquez 63, Eto'o 90 |
| 05/01/08 | Espanyol Tamudo 9, 36, Valdo 14 | 3-0 | Villarreal |
| 06/01/08 | Getafe | 0-3 | Valladolid Vivar Dorado 54, 76, Alvaro Rubio 68 |
| 06/01/08 | Recreativo Sinama Pongolle 15 | 1-1 | Almería Mane 20 |
| 06/01/08 | Deportivo | 0-3 | Atlético Forlan 39, Aguero 52, Jurado 65 |
| 06/01/08 | Valencia | 0-0 | Levante |
| 06/01/08 | Murcia Goitom 73, Abel 90(p) | 2-0 | Osasuna |
| 06/01/08 | Racing Tchite 43 | 1-0 | Athletic |
| 06/01/08 | Real Madrid van Nistelrooy 66, Robinho 77 | 2-0 | Zaragoza |
| 06/01/08 | Sevilla Luis Fabiano 26, 42, Daniel 63 | 3-0 | Betis |
| 12/01/08 | Barcelona Gudjohnsen 27, Bojan 52, Eto'o 77, 87 | 4-0 | Murcia |
| 12/01/08 | Athletic Yeste 28, Susaeta 68 | 2-0 | Sevilla |
| 13/01/08 | Zaragoza Diego Milito 24, 37 | 2-2 | Mallorca Varela 17, Guiza 62 |
| 13/01/08 | Osasuna | 0-2 | Racing Colsa 83, Pablo Alvarez 84 |
| 13/01/08 | Betis Pavone 5, 60, Edu 35 | 3-2 | Getafe Manu 78, De la Red 62(p) |
| 13/01/08 | Valladolid Llorente 8, 22, 87 | 3-1 | Recreativo Camunas 44 |
| 13/01/08 | Almería Uche 87 | 1-0 | Espanyol |
| 13/01/08 | Villarreal Rossi 31(p), Nihat 66, 68, Tomasson 80(p) | 4-3 | Deportivo Sergio 27(p), Pablo Amo 58, Guardado 90 |
| 13/01/08 | Levante | 0-2 | Real Madrid van Nistelrooy 76(p), 87 |
| 13/01/08 | Atlético Aguero 28 | 1-0 | Valencia |
| 19/01/08 | Getafe Casquero 33, Albin 58, Contra 90 | 3-2 | Sevilla Luis Fabiano 16, Dragutinovic 89 |
| 19/01/08 | Villarreal Pires 7, Capdevila 63, Nihat 70 | 3-0 | Valencia |
| 20/01/08 | Almería Pulido 90 | 1-0 | Deportivo |
| 20/01/08 | Valladolid Llorente 1, 34 | 2-1 | Espanyol Torrejon 59 |
| 20/01/08 | Betis Edu 57 | 1-1 | Recreativo Javi Guerrero 59 |
| 20/01/08 | Zaragoza Oliveira 34, Diego Milito 62, 82 | 3-1 | Murcia Ivan Alonso 90 |
| 20/01/08 | Levante Geijo 19, Alvaro 88 | 2-2 | Mallorca Guiza 31, 77 |
| 20/01/08 | Osasuna Dady 68, Vela 69 | 2-0 | Athletic |
| 20/01/08 | Atlético | 0-2 | Real Madrid Raul 1, van Nistelrooy 42 |
| 20/01/08 | Barcelona Henry 31 | 1-0 | Racing |
| 26/01/08 | Sevilla Poulsen 56, Luis Fabiano 90(p) | 2-1 | Osasuna Kike Sola 70 |
| 27/01/08 | Racing Bolado 4, Tchite 90 | 2-2 | Zaragoza Diego Milito 61, Celades 84 |
| 27/01/08 | Murcia Ivan Alonso 47, Rosinei 89 | 2-3 | Levante Alvaro 73, Riga 82(p), Pedro Leon 90 |
| 27/01/08 | Mallorca Arango 21 | 1-0 | Atlético |
| 27/01/08 | Valencia | 0-1 | Almería Felipe Melo 20 |
| 27/01/08 | Deportivo Lopo 8, Xisco 46, Guardado 72 | 3-1 | Valladolid Victor 83 |
| 27/01/08 | Espanyol Luis Garcia 52 | 1-2 | Betis Rivera 44, Edu 90 |
| 27/01/08 | Recreativo Camunas 16 | 1-3 | Getafe Albin 2, Granero 44, Manu 90 |
| 27/01/08 | Athletic Llorente 79 | 1-1 | Barcelona Bojan 34 |
| 27/01/08 | Real Madrid Robinho 8, 54, Sneijder 77 | 3-2 | Villarreal Rossi 15, Capdevila 76 |
