| 01/12/07 | Almería Acasiete 88 | 1-0 | Sevilla |
| 01/12/07 | Real Madrid Raul 4, 70, Sergio Sanchez 11(o) | 3-1 | Racing Munitis 73 |
| 01/12/07 | Espanyol Coro 69 | 1-1 | Barcelona Iniesta 6 |
| 02/12/07 | Getafe Braulio 62, 90 | 2-1 | Levante Riga 16 |
| 02/12/07 | Recreativo Carlos Martins 26, 41 | 2-1 | Zaragoza Diego Milito 22 |
| 02/12/07 | Deportivo Taborda 83 | 1-2 | Osasuna Plasil 47, Dady 88 |
| 02/12/07 | Mallorca Webo 68 | 1-1 | Murcia Inigo 24 |
| 02/12/07 | Valladolid Llorente 19, Victor 58 | 2-0 | Villarreal |
| 02/12/07 | Betis | 0-2 | Atlético Forlan 34, Raul Garcia 90 |
| 02/12/07 | Valencia | 0-3 | Athletic Yeste 33, Llorente 61, 90 |
| 05/12/07 | Osasuna Plasil 19 | 1-1 | Sevilla Jesus Navas 47 |
| 08/12/07 | Osasuna | 0-0 | Valencia |
| 08/12/07 | Athletic | 0-1 | Real Madrid van Nistelrooy 54 |
| 09/12/07 | Almería Negredo 76 | 1-0 | Valladolid |
| 09/12/07 | Villarreal | 0-1 | Betis Capi 10 |
| 09/12/07 | Levante | 0-2 | Recreativo Camunas 38, Jesus Vazquez 54 |
| 09/12/07 | Zaragoza Diego Milito 5, Oliveira 86, 89 | 3-3 | Espanyol Tamudo 8, Valdo 11, Zabaleta 15 |
| 09/12/07 | Racing Jorge Lopez 20, Duscher 30, Munitis 84 | 3-1 | Mallorca Webo 12 |
| 09/12/07 | Sevilla Luis Fabiano 5, 90, Maresca 60(p) | 3-1 | Murcia Baiano 67 |
| 09/12/07 | Atlético Forlan 20 | 1-0 | Getafe |
| 09/12/07 | Barcelona Ronaldinho 40(p), Xavi 71 | 2-1 | Deportivo Cristian 3 |
| 15/12/07 | Espanyol Jarque 9 | 1-0 | Levante |
| 15/12/07 | Valencia | 0-3 | Barcelona Eto'o 13, 27, Gudjohnsen 62 |
| 16/12/07 | Mallorca | 0-0 | Athletic |
| 16/12/07 | Murcia Goitom 57, Baiano 83(p) | 2-1 | Racing Smolarek 63 |
| 16/12/07 | Deportivo Coloccini 53 | 1-1 | Zaragoza Diego Milito 19 |
| 16/12/07 | Valladolid | 0-0 | Sevilla |
| 16/12/07 | Betis Edu 29(p), Pavone 51, 82 | 3-1 | Almería Negredo 10(p) |
| 16/12/07 | Getafe Kepa 86 | 1-3 | Villarreal Nihat 16, 79, Santi Cazorla 84 |
| 16/12/07 | Recreativo | 0-0 | Atlético |
| 16/12/07 | Real Madrid van Nistelrooy 16, Sneijder 75 | 2-0 | Osasuna |
| 22/12/07 | Almería | 0-2 | Getafe Licht 37, De la Red 85 |
| 22/12/07 | Zaragoza Diego Milito 18(p), Sergio Garcia 29 | 2-2 | Valencia Zigic 77, Silva 83 |
| 22/12/07 | Sevilla Kanoute 26, Chevanton 66, Jesus Navas 85, Adriano Correia 90 | 4-1 | Racing Garay 49 |
| 23/12/07 | Osasuna Hector Font 9, Plasil 48, Hugo Viana 90 | 3-1 | Mallorca Guiza 50 |
| 23/12/07 | Valladolid | 0-0 | Betis |
| 23/12/07 | Villarreal Nihat 39 | 1-1 | Recreativo Camunas 37 |
| 23/12/07 | Atlético Simao 36 | 1-2 | Espanyol Tamudo 52, Luis Garcia 83 |
| 23/12/07 | Levante | 0-1 | Deportivo Sergio 85(p) |
| 23/12/07 | Barcelona | 0-1 | Real Madrid Julio Baptista 36 |
| 23/12/07 | Athletic Koikili 45 | 1-1 | Murcia Baiano 54(p) |
