| 05/04/08 | Osasuna | 0-1 | Recreativo Sinama Pongolle 37 |
| 05/04/08 | Mallorca Borja Valero 72 | 1-1 | Real Madrid Sneijder 43 |
| 06/04/08 | Atlético Antonio Lopez 3, Forlan 6(p), Simao 34, 45, Aguero 54, 71 | 6-3 | Almería Felipe Melo 11, Ortiz 18, Negredo 37 |
| 06/04/08 | Levante | 0-3 | Valladolid Llorente 23, Victor 59, Borja 88 |
| 06/04/08 | Zaragoza | 0-3 | Betis Gonzalez 9, 17, Pavone 63 |
| 06/04/08 | Athletic Garmendia 14 | 1-0 | Espanyol |
| 06/04/08 | Racing Jorge Lopez 37 | 1-3 | Deportivo Xisco 2, 43, Coloccini 25 |
| 06/04/08 | Murcia Ivan Alonso 36 | 1-0 | Valencia |
| 06/04/08 | Sevilla Luis Fabiano 19, Kanoute 87(p) | 2-0 | Villarreal |
| 06/04/08 | Barcelona | 0-0 | Getafe |
| 12/04/08 | Valencia Villa 65(p) | 1-2 | Racing Colsa 61, Tchite 83 |
| 12/04/08 | Recreativo Ruben 42, 71 | 2-2 | Barcelona Eto'o 1, 46 |
| 13/04/08 | Valladolid Ogbeche 89 | 1-1 | Atlético Maxi 68 |
| 13/04/08 | Betis | 0-1 | Levante Pedro Leon 54 |
| 13/04/08 | Getafe | 0-0 | Zaragoza |
| 13/04/08 | Espanyol | 0-1 | Osasuna Astudillo 31 |
| 13/04/08 | Deportivo Coloccini 31, Sergio 64(p), Filipe 79 | 3-0 | Athletic |
| 13/04/08 | Mallorca Guiza 47, Webo 90 | 2-3 | Sevilla Renato 43, Kanoute 67, Daniel 76 |
| 13/04/08 | Real Madrid Sneijder 58 | 1-0 | Murcia |
| 13/04/08 | Almería Acasiete 84 | 1-0 | Villarreal |
| 19/04/08 | Barcelona | 0-0 | Espanyol |
| 19/04/08 | Atlético Aguero 26 | 1-3 | Betis Juande 15, Xisco 49, Capi 66 |
| 19/04/08 | Zaragoza Sergio Garcia 2, Oliveira 21, 78 | 3-0 | Recreativo |
| 19/04/08 | Sevilla Kanoute 73 | 1-4 | Almería Daniel 24(o), Negredo 47, 66, Ortiz 62 |
| 20/04/08 | Murcia Baiano 88 | 1-4 | Mallorca Guiza 7, 46, 85, Arango 18 |
| 20/04/08 | Villarreal Nihat 15, Santi Cazorla 46 | 2-0 | Valladolid |
| 20/04/08 | Levante Juanma 40, Berson 44, Pedro Leon 53 | 3-1 | Getafe De la Red 60(p) |
| 20/04/08 | Osasuna | 0-1 | Deportivo Sergio 65(p) |
| 20/04/08 | Racing | 0-2 | Real Madrid Raul 13, Higuain 90 |
| 20/04/08 | Athletic Javi Martinez 19, Llorente 49, 66, Iraola 85, Aduriz 90 | 5-1 | Valencia Villa 75 |
| 26/04/08 | Deportivo Juan Rodriguez 54, Pablo Amo 76 | 2-0 | Barcelona |
| 26/04/08 | Murcia | 0-0 | Sevilla |
| 27/04/08 | Valladolid Sesma 90 | 1-0 | Almería |
| 27/04/08 | Getafe Gavilan 13 | 1-1 | Atlético Aguero 39 |
| 27/04/08 | Recreativo Martin 10, Camunas 42 | 2-0 | Levante |
| 27/04/08 | Espanyol Riera 59 | 1-1 | Zaragoza Oliveira 84(p) |
| 27/04/08 | Valencia Villa 20(p), Mata 51, Joaquin 82 | 3-0 | Osasuna |
| 27/04/08 | Mallorca Nunes 46, Trejo 82, Guiza 90 | 3-1 | Racing Duscher 87(p) |
| 27/04/08 | Betis | 0-1 | Villarreal Senna 16 |
| 27/04/08 | Real Madrid Saviola 15, Robben 74, Higuain 76 | 3-0 | Athletic |
