| 02/11/07 | Willem II Kargbo 10 | 1-2 | Venlo Soltani 73, Kahya 83 |
| 03/11/07 | Heerenveen Bak Nielsen 32, Sulejmani 70 | 2-1 | PSV Lazovic 29 |
| 03/11/07 | AZ Cziommer 13, Jaliens 19, Ari 33, De Zeeuw 66 | 4-0 | NEC |
| 03/11/07 | Excelsior Den Ouden 34(p), 43, Voskamp 88, Luyckx 90 | 4-3 | Sparta Rose 18, Roberts 40, Boukhari 65 |
| 04/11/07 | Utrecht | 0-1 | NAC Amoah 75 |
| 04/11/07 | Feyenoord De Guzman 54, Makaay 58(p) | 2-0 | De Graafschap |
| 04/11/07 | Ajax Huntelaar 22, Suarez 42, Luque 47, Rommedahl 90 | 4-2 | Roda Lamah 39, Hadouir 76 |
| 04/11/07 | Heracles | 0-3 | Twente Denneboom 24, N'Kufo 81, Engelaar 90 |
| 04/11/07 | Groningen | 0-0 | Vitesse |
| 09/11/07 | NEC van Beukering 33, Lens 82, Nalbantoglu 90 | 3-0 | Heracles |
| 10/11/07 | Willem II Poepon 67 | 1-4 | Utrecht Nelisse 35, George 43, Broerse 89, Peters 79 |
| 10/11/07 | Venlo Oost 59, Amrabat 87 | 2-0 | Sparta |
| 10/11/07 | Twente Wilkshire 23 | 1-1 | NAC Amoah 16 |
| 10/11/07 | De Graafschap Fung A Wing 18 | 1-1 | Excelsior Van Guldener 87 |
| 11/11/07 | Feyenoord Van Bronckhorst 29, De Guzman 74 | 2-2 | Ajax Rommedahl 53, de Jong 67 |
| 11/11/07 | PSV Farfan 59 | 1-1 | AZ Ari 36 |
| 11/11/07 | Vitesse | 0-1 | Heerenveen Bradley 50 |
| 11/11/07 | Roda Hadouir 1, Lamah 23, Oper 36, 51, Cisse 62 | 5-1 | Groningen Nevland 20 |
| 23/11/07 | NAC | 0-0 | Roda |
| 24/11/07 | Heerenveen Dingsdag 25, Pranjic 74(p) | 2-3 | De Graafschap De Groot 13, Schone 42, Powel 67 |
| 24/11/07 | AZ Ari 25, Dembele 44 | 2-0 | Willem II |
| 24/11/07 | Excelsior Pardo 71 | 1-4 | PSV Bakkal 23, Koevermans 57, Lazovic 58, Perez 76(p) |
| 24/11/07 | Heracles | 0-0 | Venlo |
| 25/11/07 | Utrecht Van Dijk 19, George 54, Rossini 89 | 3-2 | NEC Olsson 17, Davids 57 |
| 25/11/07 | Sparta Polak 21 | 1-1 | Twente Engelaar 71 |
| 25/11/07 | Ajax Suarez 17, Gabri 27, Luque 44(p), Huntelaar 82 | 4-1 | Vitesse Junker 45 |
| 25/11/07 | Groningen Berg 72, 90, Nevland 75 | 3-2 | Feyenoord Makaay 11, Sahin 77 |
| 30/11/07 | Utrecht Loval 7, 29, 88, Nelisse 31, 60, George 36, Dickoh 44 | 7-1 | Sparta Rose 77 |
