| 01/03/08 | Roda Janssen 4 | 1-1 | AZ Cziommer 80 |
| 01/03/08 | NAC Feher 9, Lurling 57, 81 | 3-0 | Sparta |
| 01/03/08 | Twente Hersi 78 | 1-0 | Heerenveen |
| 01/03/08 | De Graafschap Tarvajarvi 3 | 1-2 | Willem II Kargbo 40, Demouge 58 |
| 02/03/08 | Utrecht Nelisse 36, Cornelisse 44, Van Dijk 75(p) | 3-1 | PSV Simons 28(p) |
| 02/03/08 | Feyenoord Van Bronckhorst 39 | 1-3 | NEC Holman 17, Olsson 79, Lens 90 |
| 02/03/08 | Ajax Huntelaar 26, 40, Emanuelson 55, Leonardo 85 | 4-0 | Excelsior |
| 02/03/08 | Groningen Powel 9 | 1-2 | Heracles Ramos da Silva 14, Lakic 73 |
| 07/03/08 | Heracles Ramos da Silva 29, Lakic 73 | 2-1 | Utrecht Cornelisse 68 |
| 08/03/08 | Heerenveen Bradley 32, Sulejmani 38, 78 | 3-0 | NAC |
| 08/03/08 | Willem II Van Der Struijk 37(p) | 1-2 | Groningen Baelum 82(o), De Roover 84 |
| 08/03/08 | Excelsior Voskamp 70(p) | 1-2 | Vitesse Prijor 35, Lorca 86 |
| 08/03/08 | NEC Holman 33, 75, Vadocz 48 | 3-1 | De Graafschap Tarvajarvi 60 |
| 09/03/08 | Sparta Roberts 18, Rutjes 23, Emnes 51, 60 | 4-1 | Roda Matondo 65 |
| 11/03/08 | VVV | 0-2 | Twente Franco 19, Hersi 77 |
| 12/03/08 | AZ | 0-1 | Feyenoord De Guzman 20 |
| 14/03/08 | Groningen | 0-1 | Heerenveen Sulejmani 85 |
| 15/03/08 | NAC Idabdelhay 45, Kolkka 60 | 2-0 | Excelsior |
| 15/03/08 | Twente Denneboom 4, N'Kufo 48, 85, Hersi 77 | 4-3 | Vitesse Kolk 38, 46, Claudemir 90 |
| 15/03/08 | De Graafschap | 0-0 | Heracles |
| 15/03/08 | Feyenoord Bruins 5, Van Bronckhorst 33, Mols 44, Sahin 58 | 4-1 | VVV Honda 13 |
| 16/03/08 | Utrecht Van der Gun 62, Vandenbergh 84 | 2-2 | AZ De Zeeuw 53, El Hamdaoui 90 |
| 16/03/08 | Ajax Huntelaar 29, Suarez 45, 51, 88 | 4-1 | Willem II Demouge 18 |
| 16/03/08 | NEC Bobson 61, Pothuizen 82, 86, El Akchaoui 90 | 4-2 | Sparta Emnes 2, 64 |
| 16/03/08 | Roda Meeuwis 90 | 1-1 | PSV Farfan 67 |
| 19/03/08 | PSV | 0-0 | Ajax |
| 21/03/08 | Vitesse Claudemir 35, Kolk 52, 57 | 3-3 | NAC Idabdelhay 3, Van der Schaaf 16(o), Molhoek 39 |
| 22/03/08 | Heerenveen Bradley 34, 61, Henrique 47, Beerens 51 | 4-3 | Roda Lamah 24, Matondo 27, Janssen 37 |
| 22/03/08 | PSV Koevermans 33, 84, Bakkal 47 | 3-0 | Groningen |
| 22/03/08 | Excelsior | 0-2 | Utrecht Van Dijk 12, Nelisse 84 |
| 22/03/08 | AZ | 0-0 | De Graafschap |
| 23/03/08 | VVV Honda 34 | 1-2 | NEC Van Beukering 79, Sibum 90 |
| 23/03/08 | Sparta Boukhari 15, 50, Emnes 90 | 3-2 | Feyenoord Lucius 12, Van Bronckhorst 62 |
| 23/03/08 | Willem II Mourad 46, Demouge 68 | 2-1 | Heracles Schilder 71 |
| 23/03/08 | Twente Wilkshire 71, Elia 90 | 2-1 | Ajax Franco 63(o) |
| 28/03/08 | De Graafschap Johnson 83 | 1-1 | Groningen Powel 45 |
| 29/03/08 | Heerenveen Sulejmani 60, Pranjic 90 | 2-4 | Ajax Suarez 44, Perez 55(p), Huntelaar 61, 89 |
| 29/03/08 | Excelsior van Steensel 78, Braber 80 | 2-1 | VVV Soltani 10 |
| 29/03/08 | Heracles | 0-0 | Roda |
| 29/03/08 | NEC | 0-0 | PSV |
| 30/03/08 | NAC Elshot 32, Molhoek 40, Amoah 72 | 3-1 | Feyenoord Fer 10 |
| 30/03/08 | Utrecht | 0-1 | Twente Huysegems 90 |
| 30/03/08 | Sparta Rose 69, John 73 | 2-2 | Willem II Messoudi 50, Demouge 54 |
| 30/03/08 | AZ Moreno 22, Jenner 72 | 2-1 | Vitesse Swerts 29 |
