| 01/12/07 | Roda Lamah 45, 46, Saeijs 69 | 3-2 | Vitesse Sansoni 77, Gommans 84 |
| 01/12/07 | Groningen Berg 52 | 1-0 | Venlo |
| 01/12/07 | Willem II Poepon 9, 88, Demouge 29, 80, Boutahar 59, Van Der Struijk 78(p) | 6-0 | Excelsior |
| 01/12/07 | De Graafschap | 0-1 | PSV Farfan 45 |
| 02/12/07 | Feyenoord Makaay 1, 27, Hofland 41, Slory 67, Van Bronckhorst 73, Wijnaldum 74 | 6-0 | Heracles |
| 02/12/07 | Twente N'Kufo 43, 60 | 2-1 | AZ Pelle 72 |
| 02/12/07 | Ajax Huntelaar 90 | 1-3 | NAC Vertonghen 25(o), Amoah 69, Ammi 88 |
| 02/12/07 | NEC | 0-1 | Heerenveen Poulsen 41 |
| 07/12/07 | PSV Koevermans 80, 84 | 2-4 | Roda De Fauw 19, Meeuwis 45, Oper 48, Hadouir 64 |
| 08/12/07 | Willem II Bobson 6, Swinkels 74 | 2-3 | Ajax Bakircioglu 2, Suarez 30, Vertonghen 45 |
| 08/12/07 | Excelsior | 0-3 | NAC Zwaanswijk 57, Amoah 75, Elshot 88 |
| 08/12/07 | Heracles Gluscevic 57, Quanaan 65 | 2-0 | De Graafschap |
| 08/12/07 | Vitesse Junker 25, 43 | 2-2 | Twente Denneboom 39, Hersi 82 |
| 09/12/07 | Venlo | 0-0 | Feyenoord |
| 09/12/07 | Heerenveen Lovre 2(o), Bradley 7, 23, 41 | 4-2 | Groningen Nevland 9, 14 |
| 09/12/07 | Sparta Rose 38 | 1-0 | NEC |
| 09/12/07 | AZ Pocognoli 19, De Zeeuw 25 | 2-1 | Utrecht Keller 90 |
| 14/12/07 | Roda Schenkel 67(o), Meeuwis 78(p) | 2-3 | Sparta Polak 22, Roberts 48, 62 |
| 15/12/07 | NAC Tamerus 75 | 1-5 | Heerenveen Sibon 24, 55, Sulejmani 50, Henrique 68, 73 |
| 15/12/07 | Twente N'Kufo 16(p) | 1-1 | Venlo Amrabat 13 |
| 15/12/07 | De Graafschap Schone 65 | 1-1 | NEC El Akchaoui 90 |
| 16/12/07 | Utrecht Van Dijk 45, 69(p), George 85 | 3-1 | Heracles Bosnar 90 |
| 16/12/07 | Vitesse Kolk 50, 90, Gommans 88(p) | 3-0 | Excelsior |
| 16/12/07 | Groningen Silva 54 | 1-0 | Willem II |
| 21/12/07 | Willem II Van Der Struijk 19(p) | 1-2 | De Graafschap Powel 24, De Groot 35 |
| 22/12/07 | Heerenveen Alves 41 | 1-2 | Twente N'Kufo 33(p), Denneboom 66 |
| 22/12/07 | PSV Perez 16, 68, Lazovic 64, Koevermans 85 | 4-1 | Utrecht George 46 |
| 22/12/07 | Heracles Quansah 11 | 1-2 | Groningen Niljand 24, Van Der Laak 47 |
| 23/12/07 | Excelsior Pique 1, Den Ouden 49 | 2-1 | Ajax Maduro 63 |
| 23/12/07 | NEC | 0-2 | Feyenoord Slory 48, De Guzman 60 |
| 23/12/07 | Venlo Amrabat 54, 68 | 2-0 | Vitesse |
| 23/12/07 | AZ Pelle 5 | 1-1 | Roda Matondo 53 |
| 26/12/07 | Feyenoord Makaay 4, 74 | 2-0 | Sparta |
| 26/12/07 | NEC Janssen 12, 55 | 2-2 | Venlo Kantelberg 70, Calabro 83 |
| 26/12/07 | Groningen Lindgren 61, Berg 76 | 2-1 | PSV Alcides 18 |
| 27/12/07 | Utrecht Nelisse 9, George 37, Dickoh 64, Loval 86 | 4-1 | Excelsior Van Guldener 62 |
| 27/12/07 | NAC De Graaf 90(p) | 1-2 | Vitesse Kolk 41, Gommans 51 |
| 27/12/07 | Roda Tiote 1 | 1-0 | Heerenveen |
| 27/12/07 | Ajax Huntelaar 32, 76 | 2-2 | Twente Huysegems 61, N'Kufo 90 |
| 27/12/07 | Heracles Quansah 86 | 1-0 | Willem II |
| 29/12/07 | Sparta De Roover 44 | 1-3 | Groningen Niljand 30, 53, Lovre 81 |
| 30/12/07 | Venlo | - | Ajax |
| 30/12/07 | Heerenveen Sibon 87 | 1-1 | Feyenoord Slory 17 |
| 30/12/07 | AZ Steinsson 71 | 1-0 | Heracles |
| 30/12/07 | Willem II Poepon 14, 52, 84 | 3-0 | NEC |
| 30/12/07 | Twente Huysegems 20, N'Kufo 34 | 2-0 | De Graafschap |
| 30/12/07 | PSV Koevermans 45, Perez 90 | 2-0 | NAC |
| 30/12/07 | Excelsior Voskamp 86 | 1-2 | Roda Cisse 28, Bodor 74 |
| 30/12/07 | Vitesse Gommans 3, Junker 48 | 2-2 | Utrecht Dickoh 16, Loval 65 |
