| 04/04/08 | Roda | 0-2 | NEC Van Beukering 32, Lens 67 |
| 05/04/08 | Willem II Boutahar 3, Poepon 65 | 2-3 | Heerenveen Pranjic 27(p), Beerens 31, Sibon 74 |
| 05/04/08 | Twente Hersi 59 | 1-0 | Excelsior |
| 05/04/08 | Vitesse Junker 58, Janssen 78, Claudemir 80 | 3-0 | Sparta |
| 06/04/08 | VVV Oost 3, Amrabat 64(p) | 2-3 | AZ Ari 23, El Hamdaoui 65, 73 |
| 06/04/08 | Groningen Lovre 46 | 1-2 | NAC Ammi 18, Amoah 42 |
| 06/04/08 | Feyenoord Bruins 34, Landzaat 38, Sahin 66 | 3-1 | Utrecht Nelisse 74 |
| 06/04/08 | Ajax Huntelaar 4, 9, 41, Perez 63 | 4-1 | De Graafschap Tarvajarvi 32 |
| 06/04/08 | PSV Simons 12, Farfan 80 | 2-0 | Heracles |
| 13/04/08 | Sparta Dissels 55, Boukhari 63, Polak 73(p), Emnes 80 | 4-2 | Heerenveen Pranjic 13, Sibon 44 |
| 13/04/08 | Willem II Demouge 7, 19, Boutahar 36 | 3-1 | Feyenoord Andre Bahia 74 |
| 13/04/08 | PSV Farfan 68 | 1-1 | Twente Nkufo 35 |
| 13/04/08 | Excelsior Luyckx 60 | 1-1 | AZ Donk 69 |
| 13/04/08 | Heracles | 0-1 | NAC De Graaf 58 |
| 13/04/08 | De Graafschap Johnson 72 | 1-1 | Utrecht Van der Gun 76 |
| 13/04/08 | NEC Vadocz 22 | 1-0 | Vitesse |
| 13/04/08 | Roda Meeuwis 37(p), Lamah 51, Bodor 53, Hadouir 78 | 4-1 | VVV Soltani 21 |
| 16/04/08 | Groningen Cahais 45 | 1-2 | Ajax Lindgren 19, Suarez 66 |
| 20/04/08 | Heerenveen Sibon 8, 77, Sulejmani 45, Bandjar 54(o), Arend Roorda 80 | 5-0 | Excelsior |
| 20/04/08 | Utrecht Pieters 46 | 1-0 | Groningen |
| 20/04/08 | Feyenoord Bruins 65, Sahin 77, Mols 88 | 3-0 | Roda |
| 20/04/08 | AZ El Hamdaoui 14 | 1-0 | Sparta |
| 20/04/08 | NAC Amoah 27 | 1-3 | NEC Lens 32, 87, Van Beukering 65 |
| 20/04/08 | Twente Hersi 52, 79 | 2-0 | Willem II |
| 20/04/08 | Ajax Suarez 4, Perez 18, 73, Huntelaar 29, Heitinga 79 | 5-1 | Heracles Klavan 54 |
| 20/04/08 | Vitesse | 0-1 | PSV Lazovic 47 |
| 20/04/08 | VVV Volmer 56(o), Amrabat 63, Ofrany 83 | 3-0 | De Graafschap |
