| 01/09/07 | Bolton Anelka 54 | 1-2 | Everton Yakubu 10, Lescott 89 |
| 01/09/07 | Fulham Dempsey 41, Smertin 76, Kamara 89 | 3-3 | Tottenham Kaboul 9, Berbatov 27, Bale 60 |
| 01/09/07 | Liverpool Alonso 26, 68, Babel 45, Torres 55, 77, Voronin 75 | 6-0 | Derby |
| 01/09/07 | Middlesbrough Wheater 11, Downing 36 | 2-0 | Birmingham |
| 01/09/07 | Newcastle Owen 86 | 1-0 | Wigan |
| 01/09/07 | Reading | 0-3 | West Ham Bellamy 6, Etherington 48, 90 |
| 01/09/07 | Man. United Saha 71 | 1-0 | Sunderland |
| 02/09/07 | Arsenal Adebayor 7(p), Fabregas 34, Rosicky 58 | 3-1 | Portsmouth Kanu 59 |
| 02/09/07 | Blackburn McCarthy 12 | 1-0 | Man. City |
| 02/09/07 | Villa Knight 46, Agbonlahor 87 | 2-0 | Chelsea |
| 15/09/07 | Everton | 0-1 | Man. United Vidic 82 |
| 15/09/07 | Portsmouth | 0-0 | Liverpool |
| 15/09/07 | Tottenham Bale 14 | 1-3 | Arsenal Adebayor 64, 90, Fabregas 79 |
| 15/09/07 | West Ham Bowyer 45, Young 50(o), Ashton 61 | 3-0 | Middlesbrough |
| 15/09/07 | Wigan Koumas 79(p) | 1-1 | Fulham Dempsey 10 |
| 15/09/07 | Birmingham Kapo 36 | 1-0 | Bolton |
| 15/09/07 | Sunderland Jones 28, Wallace 46 | 2-1 | Reading Kitson 84 |
| 15/09/07 | Chelsea | 0-0 | Blackburn |
| 16/09/07 | Man. City Johnson 47 | 1-0 | Villa |
| 17/09/07 | Derby Miller 38 | 1-0 | Newcastle |
| 22/09/07 | Arsenal Diaby 9, Adebayor 24, 49(p), 78, Fabregas 69 | 5-0 | Derby |
| 22/09/07 | Liverpool | 0-0 | Birmingham |
| 22/09/07 | Middlesbrough Arca 14, Downing 66 | 2-2 | Sunderland Leadbitter 1, Miller 88 |
| 22/09/07 | Reading Kitson 28, Harper 89 | 2-1 | Wigan Bent 49 |
| 22/09/07 | Fulham Davies 12, Bouazza 47, Murphy 74 | 3-3 | Man. City Petrov 35, 59, Mpenza 49 |
| 23/09/07 | Newcastle Viduka 2, 40, N'Zogbia 75 | 3-1 | West Ham Ashton 31 |
| 23/09/07 | Villa Carew 13, Agbonlahor 59 | 2-0 | Everton |
| 23/09/07 | Bolton Campo 38 | 1-1 | Tottenham Keane 33 |
| 23/09/07 | Blackburn | 0-1 | Portsmouth Kanu 24 |
| 23/09/07 | Man. United Tevez 45, Saha 89(p) | 2-0 | Chelsea |
| 29/09/07 | Man. City Petrov 37, Mpenza 46, Elano 86 | 3-1 | Newcastle Martins 28 |
| 29/09/07 | Chelsea | 0-0 | Fulham |
| 29/09/07 | Derby Miller 18 | 1-1 | Bolton Anelka 31 |
| 29/09/07 | Portsmouth Mwaruwari 6, 36, 69, Hreidarsson 54, Kranjcar 74, Davis 80, Muntari 90(p) | 7-4 | Reading Hunt 45, Kitson 47, Long 78, Shorey 90 |
| 29/09/07 | Sunderland Leadbitter 89 | 1-2 | Blackburn Bentley 52, Santa Cruz 54 |
| 29/09/07 | West Ham | 0-1 | Arsenal Van Persie 12 |
| 29/09/07 | Wigan | 0-1 | Liverpool Benayoun 74 |
| 29/09/07 | Birmingham | 0-1 | Man. United Ronaldo 50 |
| 30/09/07 | Everton Lescott 6, Pienaar 57 | 2-0 | Middlesbrough |
