| 01/10/07 | Tottenham Berbatov 19, Chimbonda 68, Keane 81(p), Kaboul 90 | 4-4 | Villa Laursen 22, 32, Agbonlahor 39, Gardner 58 |
| 06/10/07 | Man. United Tevez 53, Ronaldo 58, 75, Rooney 81 | 4-0 | Wigan |
| 06/10/07 | Villa Gardner 23 | 1-0 | West Ham |
| 07/10/07 | Arsenal Van Persie 6, 79, Senderos 13 | 3-2 | Sunderland Wallace 24, Jones 47 |
| 07/10/07 | Reading Doyle 62 | 1-0 | Derby |
| 07/10/07 | Man. City Riggott 9(o), Elano 32, 62 | 3-1 | Middlesbrough Hutchinson 88 |
| 07/10/07 | Newcastle Butt 41, Emre 85, Owen 89 | 3-2 | Everton Johnson 52, Given 90(o) |
| 07/10/07 | Blackburn Bentley 14, McCarthy 55(p) | 2-1 | Birmingham Jerome 67 |
| 07/10/07 | Bolton | 0-1 | Chelsea Kalou 40 |
| 07/10/07 | Liverpool Voronin 11, Torres 90 | 2-2 | Tottenham Keane 44, 46 |
| 07/10/07 | Fulham | 0-2 | Portsmouth Mwaruwari 49, Hreidarsson 51 |
| 20/10/07 | Everton Hyypia 37(o) | 1-2 | Liverpool Kuyt 53(p), 90(p) |
| 20/10/07 | Fulham | 0-0 | Derby |
| 20/10/07 | Man. City Elano 36 | 1-0 | Birmingham |
| 20/10/07 | Middlesbrough | 0-2 | Chelsea Drogba 7, Alex 56 |
| 20/10/07 | Wigan | 0-2 | Portsmouth Mwaruwari 80, Johnson 85 |
| 20/10/07 | Blackburn McCarthy 17, 81(p), Santa Cruz 21, Kerimoglu 31 | 4-2 | Reading Doyle 79, 90 |
| 20/10/07 | Arsenal Toure 67, Rosicky 79 | 2-0 | Bolton |
| 20/10/07 | Villa Agbonlahor 12 | 1-4 | Man. United Rooney 35, 43, Ferdinand 45, Giggs 74 |
| 21/10/07 | West Ham Cole 8, Gordon 77(o), Bellamy 90 | 3-1 | Sunderland Jones 51 |
| 22/10/07 | Newcastle Martins 44, Cacapa 50, Milner 72 | 3-1 | Tottenham Keane 56 |
| 27/10/07 | Reading Kitson 52, Long 83 | 2-1 | Newcastle Duberry 75(o) |
| 27/10/07 | Sunderland Jones 85 | 1-1 | Fulham Davies 31 |
| 27/10/07 | Birmingham Kapo 25(p), 80, Ridgewell 66 | 3-2 | Wigan Bent 22, 58 |
| 27/10/07 | Chelsea Essien 15, Drogba 30, 55, Cole 59, Kalou 74, Shevchenko 89 | 6-0 | Man. City |
| 27/10/07 | Man. United Nani 2, Rooney 32, Tevez 54, 84 | 4-1 | Middlesbrough Aliadiere 5 |
| 27/10/07 | Portsmouth | 0-0 | West Ham |
| 28/10/07 | Bolton Anelka 21 | 1-1 | Villa Moore 56 |
| 28/10/07 | Derby | 0-2 | Everton Arteta 25, Yakubu 62 |
| 28/10/07 | Tottenham Keane 48(p) | 1-2 | Blackburn McCarthy 59, Samba 90 |
| 28/10/07 | Liverpool Gerrard 6 | 1-1 | Arsenal Fabregas 79 |
