| 01/12/07 | Chelsea Cole 76 | 1-0 | West Ham |
| 01/12/07 | Portsmouth | 0-0 | Everton |
| 01/12/07 | Reading Kitson 54 | 1-1 | Middlesbrough Sanli 83 |
| 01/12/07 | Sunderland Stokes 90 | 1-0 | Derby |
| 01/12/07 | Wigan Scharner 25 | 1-1 | Man. City Geovanni 1 |
| 01/12/07 | Blackburn Bentley 54, 67, Kerimoglu 90 | 3-1 | Newcastle Martins 47 |
| 01/12/07 | Villa Gardner 14 | 1-2 | Arsenal Flamini 23, Adebayor 36 |
| 02/12/07 | Liverpool Hyypia 17, Torres 45, Gerrard 56(p), Babel 86 | 4-0 | Bolton |
| 02/12/07 | Tottenham Keane 50(p), 53 | 2-3 | Birmingham McSheffrey 24(p), Jerome 62, Larsson 90 |
| 03/12/07 | Man. United Ronaldo 10, 58 | 2-0 | Fulham |
| 05/12/07 | Newcastle Taylor 60 | 1-1 | Arsenal Adebayor 4 |
| 08/12/07 | Villa Barry 72(p) | 1-3 | Portsmouth Gardner 10(o), Muntari 40, 61 |
| 08/12/07 | Chelsea Shevchenko 23, Lampard 75(p) | 2-0 | Sunderland |
| 08/12/07 | Everton Yakubu 51, 61, 79 | 3-0 | Fulham |
| 08/12/07 | Man. United Giggs 40, Tevez 45, 60, Ronaldo 90(p) | 4-1 | Derby Howard 76 |
| 08/12/07 | Newcastle Martins 37(p), Beye 90 | 2-1 | Birmingham Jerome 9 |
| 08/12/07 | Reading Hunt 17(p), Doyle 60, Harper 67 | 3-1 | Liverpool Gerrard 28 |
| 09/12/07 | Middlesbrough Downing 4(p), Sanli 74 | 2-1 | Arsenal Rosicky 90 |
| 09/12/07 | Tottenham Chimbonda 45, Defoe 83 | 2-1 | Man. City Bianchi 61 |
| 09/12/07 | Bolton Scharner 3(o), Nolan 37, Davies 70, Anelka 89 | 4-1 | Wigan Landzaat 14 |
| 09/12/07 | Blackburn | 0-1 | West Ham Ashton 52 |
| 15/12/07 | Birmingham Forssell 4 | 1-1 | Reading Hunt 51(p) |
| 15/12/07 | Derby | 0-1 | Middlesbrough Sanli 38 |
| 15/12/07 | Man. City Bianchi 7, Michalik 48(o), Vassell 77, Etuhu 90 | 4-2 | Bolton Diouf 31, Nolan 40 |
| 15/12/07 | Portsmouth | 0-1 | Tottenham Berbatov 81 |
| 15/12/07 | Sunderland Higginbotham 10 | 1-1 | Villa Maloney 73 |
| 15/12/07 | West Ham | 0-2 | Everton Yakubu 45, Johnson 90 |
| 15/12/07 | Wigan Landzaat 10, Bent 12, 66, 81, Scharner 37 | 5-3 | Blackburn Santa Cruz 45, 50, 61 |
| 15/12/07 | Fulham | 0-1 | Newcastle Barton 90(p) |
| 16/12/07 | Liverpool | 0-1 | Man. United Tevez 43 |
| 16/12/07 | Arsenal Gallas 45 | 1-0 | Chelsea |
| 22/12/07 | Arsenal Adebayor 48, Bendtner 76 | 2-1 | Tottenham Berbatov 66 |
| 22/12/07 | Villa Carew 14 | 1-1 | Man. City Bianchi 11 |
| 22/12/07 | Bolton Diouf 72, Anelka 78, 90 | 3-0 | Birmingham |
| 22/12/07 | Fulham Dempsey 78 | 1-1 | Wigan Bent 70 |
| 22/12/07 | Liverpool Benayoun 13, Distin 16(o), Torres 67, 85 | 4-1 | Portsmouth Mwaruwari 57 |
| 22/12/07 | Middlesbrough Wheater 40 | 1-2 | West Ham Ashton 44, Parker 90 |
| 22/12/07 | Reading Ingimarsson 69, Hunt 90 | 2-1 | Sunderland Chopra 82(p) |
| 23/12/07 | Man. United Ronaldo 22, 88(p) | 2-1 | Everton Cahill 27 |
| 23/12/07 | Newcastle Viduka 27, 87 | 2-2 | Derby Barnes 6, Miller 52 |
| 23/12/07 | Blackburn | 0-1 | Chelsea Cole 22 |
| 26/12/07 | Chelsea Shevchenko 45(p), 50, Alex 66, Ballack 88 | 4-4 | Villa Maloney 14, 44, Laursen 72, Barry 90(p) |
| 26/12/07 | Tottenham Keane 27, 62, Huddlestone 45, 71, Defoe 90 | 5-1 | Fulham Dempsey 60 |
| 26/12/07 | West Ham Solano 42 | 1-1 | Reading Kitson 60 |
| 26/12/07 | Wigan Taylor 65 | 1-0 | Newcastle |
| 26/12/07 | Derby McEveley 67 | 1-2 | Liverpool Torres 12, Gerrard 90 |
| 26/12/07 | Everton Neville 51, Cahill 70 | 2-0 | Bolton |
| 26/12/07 | Birmingham Downing 22(o), Forssell 45, McSheffrey 90(p) | 3-0 | Middlesbrough |
| 26/12/07 | Sunderland | 0-4 | Man. United Rooney 20, Saha 30, 86(p), Ronaldo 45 |
| 26/12/07 | Portsmouth | 0-0 | Arsenal |
| 27/12/07 | Man. City Vassell 27, Nelsen 30(o) | 2-2 | Blackburn Santa Cruz 28, 84 |
| 29/12/07 | Birmingham Larsson 55 | 1-1 | Fulham Bocanegra 8 |
| 29/12/07 | Chelsea Essien 29, Kalou 87 | 2-1 | Newcastle Butt 56 |
| 29/12/07 | Portsmouth | 0-1 | Middlesbrough Sanli 20 |
| 29/12/07 | Sunderland Richardson 13, Jones 32, Murphy 90 | 3-1 | Bolton Diouf 41 |
| 29/12/07 | Tottenham Berbatov 7, 63, 73, 83, Malbranque 76, Defoe 79 | 6-4 | Reading Cisse 16, Ingimarsson 53, Kitson 69, 74 |
| 29/12/07 | West Ham Ferdinand 77, Upson 82 | 2-1 | Man. United Ronaldo 14 |
| 29/12/07 | Wigan Bramble 28 | 1-2 | Villa Davies 55, Agbonlahor 70 |
| 29/12/07 | Everton Cahill 19 | 1-4 | Arsenal Eduardo 47, 58, Adebayor 78, Rosicky 90 |
| 30/12/07 | Derby Oakley 27 | 1-2 | Blackburn Santa Cruz 39, Bentley 42 |
| 30/12/07 | Man. City | 0-0 | Liverpool |
